| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
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| Symposium
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Materials Science for Global Development -- Health, Energy, and Environment: An SMD Symposium in Honor of Wole Soboyejo
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| Presentation Title |
Combined Drug Release and Laser-induced Heating of Multi-component Microspheres for the Treatment of Triple-negative Breast Cancer |
| Author(s) |
Vanessa Uzonwanne, Suhani Gupta, John obayemi, Precious Etinosa, Ali Salifu |
| On-Site Speaker (Planned) |
Vanessa Uzonwanne |
| Abstract Scope |
This study presents the results of the combined effects of sustained drug release and laser-induced hyperthermia for the treatment of triple-negative breast cancer (TNBC). Multi-component microspheres containing poly(lactic-co-glycolic acid) (PLGA), plasmonic nanoparticles (magnetite and gold), and prodigiosin anticancer drug (PG) (PLGA-PG-NP) are synthesized using a single emulsion process. The microstructural and thermal properties of the PLGA-PG-NP microspheres are then characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Subsequently, the microspheres are illuminated with near-infrared laser beams to characterize their photothermal properties, as well as elucidate the effects of laser-induced heating on the kinetics of prodigiosin drug release from the microspheres.
The effects of sequential drug release and laser-induced hyperthermia on TNBC cell viability is also investigated. Finally, the implications of our findings for treating and preventing local recurrence of TNBC are discussed. |
| Proceedings Inclusion? |
Planned: |