| Abstract Scope |
Oxidative and nitrosative stress, the excessive generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), respectively, hinder the normal functioning and induces damaging effect to the cellular machinery. Specially formulated nanoceria mimics the catalytic properties of antioxidative enzymes and induces protective effect through regenerative scavenging potential and ameliorates the disease states further. Based on its synthesis methodology, nanoceria has been developed for scavenging of different toxic ROS and RNS molecules including superoxide anions, hydrogen peroxide and peroxynitrite molecules. Nanoceria has been found to accelerate the wound healing process through reducing the oxidative/nitrosative damage and inducing proliferative effect on the migration of keratinocytes, fibroblast and vascular endothelial cells. Further, nanoceria’s regenerative properties was also explored for coating of metal implants with SOD/Catalase mimetic activity to prevent osteolysis. A few examples are presented. |