| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Cancer Cell Mechanics: The Role of Actin |
| Author(s) |
Dinesh Katti, Sharad Jaswandkar, H M Nasrullah Faisal, Kalpana S Katti |
| On-Site Speaker (Planned) |
Dinesh Katti |
| Abstract Scope |
The progression of cancer is manifested by extreme morphological and mechanical changes of the cancer cells as cells cluster and form tumors. The mechanobiology of cancer cells serves as a potential biomarker for cancer progression. We have constructed tissue-engineered test-beds to mimic the progression of prostate and breast cancer metastasized to the bone site and captured the evolution of cell morphology, cytoskeleton, and mechanics of the cells during cancer progression. Computational models of cancer cells demonstrate the crucial role of cytoskeletal elements such as actin and microtubules on cell mechanics. Actin dynamics during cancer progression is captured in the test-beds. A computational multiscale framework to evaluate the mechanical response of actin and actin conformations has been developed, allowing for molecular-scale interactions and changes to actin upscaled to a finite element model of cancer cells. The results elucidate the role of actin on the mechanobiology of cancer cells during progression. |
| Proceedings Inclusion? |
Planned: Publication Outside of TMS |