| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Nanotechnology for Energy, Environment, Electronics, Healthcare and Industry
|
| Presentation Title |
H-15: Transition Metal Doped Cerium Oxide Nanozymes: Physical and Biological Characterizations for Interactions with Oxidative Stress |
| Author(s) |
Samantha Archer Stoltz, Sudipta Seal, Elayaraja Kolanthai, Craig Neal, Yifei Fu |
| On-Site Speaker (Planned) |
Samantha Archer Stoltz |
| Abstract Scope |
Cerium oxide nanoparticles (CNPs) modulate cytotoxic reactive oxygen/nitrogen species concentrations via Ce3+/Ce4+ inter-conversion, with equilibrium Ce3+-states, and related oxygen vacancy concentrations, influencing particle redox-reaction characters. We hypothesize that Zn/ Cu incorporation (5, 10, and 20 mol%) should influence surface vacancy density, as well as provide additional reaction sites with unique surface chemistry, and potentially lead to formation of NPs with broad therapeutic activity. Electron microscopy of all samples showed ~5 nm spherical particles, while X-ray diffraction and photoelectron spectroscopy and detailed Zn/Cu phase character. SOD-mimetic radical scavenging was limited across samples (ascribed to low [Ce3+], though increased slightly with increasing Zn/Cu. Interestingly, CAT-mimetic activity varied inversely with Zn-fraction, contrasting SOD trends. Further, Cu introduction showed negligible effect on CAT up to 20 mol%, whereupon activity increased substantially. In vitro studies (MTT, live/dead assays) confirmed Zn/Cu incorporation into biocompatible CNPs imparted cytotoxic character toward a breast cancer cell line (MCF-7). |