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Meeting MS&T24: Materials Science & Technology
Symposium Nanotechnology for Energy, Environment, Electronics, Healthcare and Industry
Presentation Title Multi-Scale Characterization of Riboflavin Supplements Using X-Ray Microscopy, SEM, and Automated Phase Analyses
Author(s) Andy Holwell, Ria Mitchell, Darragh Murnane
On-Site Speaker (Planned) Andy Holwell
Abstract Scope Riboflavin alleviates migraine symptoms through the reduction of neuroinflammation. The formulation includes anti-caking agents, fillers, and lubricants to maximize homogenization and bioavailability. Multi-scale characterization of supplements provides quality assurance and quantification of composition, distribution and morphology of components. Two riboflavin capsules presented very different efficacy; to understand this, novel 3D characterization techniques were used. Nanoscale X-ray microscopy was used to image the powders non-destructively in 3D, and apply advanced machine learning reconstruction to enhance visualization, improve phase contrast, and increase throughput. Automated phase classification quantified components in 3D. Additionally, correlative electron microscopy provided chemical analyses of the formulations. Each capsule’s powders exhibited large morphological and structural differences and we identified magnesium stearate binders and calcium phosphate fillers. Thus, non-destructive nanoimaging and AI-based image processing revealed previously unobservable phases. We identified and quantified components not listed as ingredients, demonstrating capability for quality assurance and regulation of supplements.

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Additive Manufacturing of Immiscible Bimetallic Composites for Biodegradable Implants
Biogenic Nanoparticles from Mango (Mangifera indica) Leaves: An Eco-Friendly Approach to Synthesis and Antimicrobial Potential of Calcium Oxide Nanoparticles
Design and Development of Compact ZnO/SnO2 Nanocomposite, ZnO and In2O3 Thin Film Metal Oxide Sensors for Methane Detection.
Enhanced Thermal Management with Two-Dimensional Nanomaterials
Fabrication of Carbon Based Non-Enzymatic Glucose Biosensor from Biogenic Raw Materials
Investigating the Antibacterial Efficacy of Ternary Oxide Nanoparticles Derived from Blended Plant Extracts with Iron, Silver, and Vanadium
Multi-Scale Characterization of Riboflavin Supplements Using X-Ray Microscopy, SEM, and Automated Phase Analyses
One-Dimensional Titanium Oxide Lepidocrocite Nanofilaments: Electronic Properties and Applications in Energy
Spectral-Domain Quantum Nanophotonics in Low-Loss Silicon Nitride

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