| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Structure and Mechanics of Bone and the Impact of Aging and Cancer |
| Author(s) |
Rizhi Wang |
| On-Site Speaker (Planned) |
Rizhi Wang |
| Abstract Scope |
A comprehensive understanding of the structure and mechanical performance of bone is essential to the development of bone repair and replacing biomaterials. From the materials point of view, human bone has up to seven levels of hierarchical structure, from the mineralized collagen fibrils at the nanometer level, to bone lamellae at the intermediate level, and the cortical and trabecular bone at the macroscopic level. This presentation will first introduce the structure and mineralization in normal bone and how they are modulated through remodeling to achieve optimal mechanical performance. The focus will be on key structural levels that lead to its extraordinary mechanical performance, especially the fracture resistance. This will be followed by our latest research progress on changes in both the structure and mineralization of bone as a result of aging and diseases such as bone metastasis. Finally, applications to the development of novel orthopaedic biomaterials will be discussed. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Composites, Mechanical Properties |