| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
Structure-property Relationships in Solvent-cast 3D-printed Polymeric Biomaterials |
| Author(s) |
Santiago Lazarte, John Tolbert, Lesley Chow, Brandon Krick |
| On-Site Speaker (Planned) |
Santiago Lazarte |
| Abstract Scope |
Interactions between cells and biomaterials are essential to regenerate functional tissue. Cells are affected both chemical and physical cues in their microenvironment. These cues can be functionally embedded in 3D-printed scaffolds to direct human mesenchymal stromal cell (hMSC) differentiation to spatially direct tissue regeneration. In many load-bearing tissue regeneration applications, including osteochondral (bone-cartilage) tissues, the mechanical properties of the scaffold must be locally tuned to perform a physiological function while new tissue is forming. This work explores how changing scaffold architecture and polymer properties affect mechanical behavior. We developed a model to explain and predict mechanical properties of printed structures. A series of scaffolds with matching compressive moduli but different architecture was printed and characterized. This approach enables us to design scaffold properties to match and support the physiological function of the native tissue and improve cell differentiation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Other |