| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Nanotechnology Enhanced Novel Bioresorbable Zn Alloy Implant for Short Bowel Syndrome Treatment |
| Author(s) |
Jingke Liu, Zeyi Guan, Yuxin Zeng, Chase Linsley, James C.Y. Dunn, Bejamin M Wu, Xiaochun Li |
| On-Site Speaker (Planned) |
Jingke Liu |
| Abstract Scope |
Short Bowel Syndrome (SBS) is a calamitous genetic disease that affects thousands of lives every year. Patients diagnosed with SBS have malabsorption and are deprived of the ability to absorb nutrition normally. Recently, a novel treatment method is developed by researchers, which uses endoscopically inserted compression springs to lengthen the diseased small intestines. However, the springs currently under development are not biodegradable. Zinc, as a recent popular biodegradable material with suitable corrosion rate and biocompatibility, poses as a promising candidate material for this application. However, zinc lacks the mechanical strength (weak yield strength and low Young’s modulus) to be employed as effective spring devices. In this study, we successfully designed and fabricated a biodegradable Zn-based alloy nanocomposite device with enhanced and tunable mechanical strengths, as well as fixture structures to meet within vivo animal testing requirements of spring devices. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Other |