| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
ACerS-ECerS Joint Symposium: Emerging Leaders in Glass and Ceramics
|
| Presentation Title |
Development of Personalized and Affordable Multi-Substituted Calcium Phosphate-Based Biomimetic Scaffolds for Bone Regeneration Applications |
| Author(s) |
Antonia Ressler, Erkka J. Frankberg, Setareh Zakeri, Martin Schwentenwein, Susanna Miettinen, Erkki Levänen |
| On-Site Speaker (Planned) |
Antonia Ressler |
| Abstract Scope |
In response to the urgent demand for innovative bone regeneration solutions, the focus of the AffordBoneS project is to develop and characterize Mg, Sr, Zn-substituted calcium phosphate scaffolds that replicate the trabecular architecture of cancellous bone. Ion substitution represents a promising approach to improve the biological effectiveness of calcium phosphates and composite materials used in bone tissue engineering applications. Porous scaffolds mimicking the natural bone structure were additively manufactured from the photosensitive ceramic suspensions for vat photopolymerization using digital light processing. The impact of the selected trace elements and the sintering temperature was investigated in relation to the obtained crystalline phase content, microstructure, elemental distribution, thermal stability, and mechanical properties. After the analysis of physicochemical properties, in vitro biological characterization was performed to determine scaffolds with best osteogenic properties regarding porosity, pore size distribution, sintering temperature and ion concentration by using stem cells from female and male donors. |