About this Abstract |
Meeting |
MS&T24: Materials Science & Technology
|
Symposium
|
Next Generation Biomaterials
|
Presentation Title |
Holmium-Doped Bioactive Glasses in Thermo-Responsive Drug Delivery Systems for Brachytherapy Allied with Bisphosphonates in Bone Cancer Treatment |
Author(s) |
Roger Borges, Agatha M. Pelosini, Juliana Marchi |
On-Site Speaker (Planned) |
Roger Borges |
Abstract Scope |
Bisphosphonates exhibit potential in bone cancer treatment by inducing cancer cell death and promoting bone regeneration. However, their efficacy diminishes when combined with bioactive glasses due to chemical inactivation on the glass surface caused by intermolecular interactions between the glass and the drug. We propose formulations utilizing a Poloxamer 407 thermo-responsive hydrogel (PL 407) matrix embedding holmium-doped bioactive glass nanoparticles, aimed at brachytherapy. Zoledronic acid (ZA) was incorporated at different concentrations (0.05 and 5 mg.mL-1) to ally drug therapy with brachytherapy. The formulations had their structure, thermoreversible and drug delivery behaviours characterized. Results demonstrate that ZA exists both "free" within the hydrogel matrix and "bonded" on the glass surface. This distinction in drug delivery mechanisms may address the challenge of utilizing bisphosphonates with bioactive glasses in brachytherapy, which was overcome, leading to the production of a drug delivery system with a selective cytotoxic effect on osteosarcoma cells. |