| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Molecular Insights Into Mineral Nanoparticle Interactions With Proteins |
| Author(s) |
Vadim G. Kessler |
| On-Site Speaker (Planned) |
Vadim G. Kessler |
| Abstract Scope |
Mineral nanoparticles (NP) are recognized as important actors in bio-interactions in soil and in living organisms. Their reactivity is often ascribed to their photo catalytical properties, but more specific enzyme-like activity in oxidation or hydrolysis of proteins, the "nanozyme" behavior is attracting an increasing attention. In the search for possibility to visualize NP interactions on molecular level, we develop approaches to isolation and characterization of protein and peptide complexes with smallest possible NP - the Poly-Oxometalate species. Structural and theoretical investigation of POM complexes with Tryptophan (Trp) permitted to reveal the molecular events in specific Trp oxidation mimicking the biological generation of plant hormones auxins. The identified mechanism was demonstrated to be realized for different NP oxidation catalysts, in particular for CeO2. The NP displaying only production of reactive oxygen species on irradiation by (UV) light cause only random oxidation of Trp, producing a variety of products lacking hormone activity. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Biomaterials, Thin Films and Interfaces |