| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Functional Biochips and Chemical Sensors Fabricated by Femtosecond Laser 3D Processing |
| Author(s) |
Koji Sugioka, Shi Bai, Kotaro Obata |
| On-Site Speaker (Planned) |
Koji Sugioka |
| Abstract Scope |
3D microfluidic SERS chips were fabricated by femtosecond-laser-assisted wet etching (femtosecond laser 3D direct writing and subsequent wet etching) followed by femtosecond laser assisted metal plating (femtosecond laser direct write ablation and subsequent electroless metal plating) and metal surface nanostructuring (laser-induced periodic surface structures: LIPSS). The fabricated microfluidic SERS chips enabled ultrasensitive analysis of large biomolecules including DNA discrimination and detection of beta-Amyloid which is a biomarker of Alzheimer's disease. Meanwhile, a new 3D fabrication method for fluoropolymer CYTOP was developed using 3D structures fabricated by femtosecond laser two-photon polymerization as molds. Importantly, refractive index of CYTOP (1.34) is almost comparable to 1.33 of the culture medium (water) for bioimaging. The fabricated 3D CYTOP micro/nanofludic chips were applied to live imaging of living cells, showing high-resolution images even near the side walls of micro/nanofluidic channels due to the refractive index matching. |