| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
BioNano Interfaces and Engineering Applications
|
| Presentation Title |
Bioinspired Interface for Titanium Implants |
| Author(s) |
Malcolm L. Snead, Candan Tamerler, Casey C Chen |
| On-Site Speaker (Planned) |
Malcolm L. Snead |
| Abstract Scope |
Expanded use of dental implants has increased the prevalence of peri-implant disease that lead to implant failure. Peri-implant disease results from microbiota dysbiogenesis triggering a host immune inflammatory response that destroys tissue. At an incidence of 14.5% with over 3 million implants placed, and growing by 500,000/year, a reduced service life ending in failure will adversely impact public health and increase health care costs. We developed an antimicrobial bifunctional peptide film to slow disease progression. Based on a high-affinity titanium binding peptide that anchors an anti-microbial peptide to the implant surface, greater than 98% coverage is achieved in <2 minutes even in the presence of contaminating protein, to produce a film durable to mechanical brushing that kills >90% of bacterial. This non-surgical approach improves oral health by delivering a simple to reapply multiple times by a water-delivered bifunctional peptide film serving to control microbial dysbiogenesis and reduce disease progression. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Biomaterials, Thin Films and Interfaces |