| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Bioinspired Ciliary Airway Implants |
| Author(s) |
Xiaoguang Dong |
| On-Site Speaker (Planned) |
Xiaoguang Dong |
| Abstract Scope |
Small-scale cilia-like devices that can manipulate fluids in narrow spaces have great potential in microfluidics, biomechanics, biomedical engineering, and other applications. However, prior studies mostly focused on artificial cilia for pumping fluids for lab-on-a-chip microfluidic applications. The design and control of artificial cilia for transporting viscous mucus in confined and tubular structures remains challenging and medical devices such as airway stents with ciliary function are still missing. Here we report a methodology to design, integrate and control artificial cilia arrays on 3D curved surfaces and showcase an airway ciliary stent for excessive mucus transportation. We encode both bioinspired non-reciprocal motion and metachronal waves for efficient fluid pumping in tubular structures. We demonstrate that a novel ciliary airway stent transports viscous porcine mucus in a lung phantom even faster than the respiratory cilia in a healthy human lung for treating various lung diseases in a minimally invasive manner. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Composites, Polymers |