| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Functional and Structural Thin Films and Coatings
|
| Presentation Title |
Grafting of Bioactive Polymers with Various Architectures for Preparing Antibacterial and Biocompatible Surfaces |
| Author(s) |
Celine Falentin-Daudre, Véronique Migonney |
| On-Site Speaker (Planned) |
Celine Falentin-Daudre |
| Abstract Scope |
Titanium (Ti) is widely used in orthopedic implants for its biocompatibility. Nevertheless and despite the prevention rules, 1,5% of implanted prostheses are still subject to bacterial infections. That’s the reason why chemical modification of titanium surfaces to confer desirable functional properties is required. Bioactive polymers such as poly(sodium styrene sulfonate) (polyNaSS) have good antibacterial properties and can improve osseointegration. In this context, we have developped 3 different techniques of polyNaSS covalent grafting onto Ti surfaces and study the influence of their architecture the in vitro biological responses of bacteria and osteoblasts. Two of them are “grafting from” techniques (thermal or UV irradiation approach). The third method is a “grafting to” technique involving an anchorage molecule onto which polyNaSS synthesized by RAFT polymerization is clicked. Overall outcomes of this investigation confirmed the significance of the sulfonate functional groups on the biological responses, regardless of the grafting method (Acta Biomaterialia, 2020). |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Titanium, Polymers |