About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials 2023
|
| Presentation Title |
Second NIR-absorbing Gelatin Stabilized Gold Nanorods with High Media and Photothermal Stability for Photothermal Cancer Therapy |
| Author(s) |
Thabang Lebepe, Samuel Oluwatobi Oluwafemi |
| On-Site Speaker (Planned) |
Samuel Oluwatobi Oluwafemi |
| Abstract Scope |
The excellent photothermal properties of gold nanorods (Au-NRs) make them one of the most researched plasmonic photothermal nanomaterials. However, their biological applications have been hampered greatly due to surfactant-induced cytotoxicity. We herein report the synthesis of highly biocompatible gelatin stabilized Au-NRs (gelatin@Au-NRs) to address this issue. The as-synthesized gelatin@Au-NRs were highly crystalline and rod-like in shape with an average length and diameter of 66.2 ± 2.3 nm and 10 ± 1.6 nm, respectively. The as-synthesized gelatin@Au-NRs showed high stability in common biological media (phosphate buffer saline and Dulbecco’s Modified Eagle’s Medium) compared to CTAB capped Au-NRs. Similarly, the gelatin@Au-NRs showed an improved heat production and outstanding cell viability against two different cancer cell lines; KM-Luc/GFP (mouse fibroblast histiocytoma cell line) and FM3A-Luc (breast carcinoma cell line) compared to CTAB capped Au-NRs and PEG@Au-NRs. In vitro, a photothermal therapy study against KM-Luc/GFP demonstrated the gelatin@Au-NRs are effectively destroying the cancer cells. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Nanotechnology |