About this Abstract |
Meeting |
2020 TMS Annual Meeting & Exhibition
|
Symposium
|
Biodegradable Materials for Medical Applications II
|
Presentation Title |
B-8: Long Term Inflammatory Response to Zinc Materials in Murine Arteries |
Author(s) |
Alexander A. Oliver, Roger J Guillory, Timothy M Kolesar, Lea M Morath, Katie L Flom, Ehsan Mostaed, Jaroslaw W Drelich, Jeremy Goldman |
On-Site Speaker (Planned) |
Alexander A. Oliver |
Abstract Scope |
Zinc alloys are under development for medical applications due to their degradation in physiological environment with nearly ideal in-vivo corrosion rate, suitable mechanical properties, and biocompatibility of corrosion by-products. However, the long-term neointimal inflammatory response and progression has yet to be characterized. Such details would make it possible to design zinc alloys with composition and surface finish that could alleviate potentially harmful inflammatory responses. In the present work, an immunofluorescence approach was used to measure the presence and distribution of conventional inflammatory markers (CD68, iNOS, and CD206) within the neointima surrounding murine arterial explants made of new zinc alloys at three, six, and eleven months post-implantation. We found a strong effect of alloying, processing and thermal treatment on the inflammatory response to arterial implants. |
Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |