| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Functional and Structural Thin Films and Coatings
|
| Presentation Title |
Design of Innovative Hybrid Structures Using Grafting of Architecture-controlled Polymers for Biomedical Applications |
| Author(s) |
Caroline Pereira, Jean-Sébastien Baumann, Patrick Masson, Geneviève Pourroy, Heinz Palkowsky, Adele Carradò, Véronique Migonney, Céline Falentin-Daudré |
| On-Site Speaker (Planned) |
Caroline Pereira |
| Abstract Scope |
Skull injuries caused by trauma and pathologies, such as tumor or congenital deformities, require the reconstruction of craniofacial prostheses. Titanium (Ti) is one of the most used materials for cranioplasty. However, this mono-material alone presents many drawbacks such as inappropriate mechanical properties compared to the bone. To solve this problem, the idea is to combine polymers and metals. Developing layered structures like sandwich materials composed of two metallic skin sheets and a copolymer core can be an interesting alternative to design innovative biomedical prostheses. To avoid Ti/Polymer/Ti structure’s delamination, we propose to chemically link polymer chains on metal surfaces by using the “grafting to” technique involving an anchorage molecule onto which the polymer synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization is clicked. Moreover, to confer antibacterial and osseointegration properties, a bioactive polymer such as poly(sodium styrene sulfonate) (polyNaSS) is grafted on the exterior surfaces of our sandwich. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Titanium, Biomaterials, Polymers |