| Abstract Scope |
Engineered biodegradable and bioresorbable materials provide promising solutions for a wide range of biomedical applications, such as implants, sensing devices, drug delivery, etc. Recent researches on biodegradable polymers and metals have demonstrated their potentials for clinical translations, but there are still major challenges yet to be addressed, e.g. (1) controlling their degradation rates with tissue healing rates, and (2) modulating their bioactivities to promote healing functions of desirable cells while inhibiting bacterial infections. In this presentation, our recent progress on developing bioresorbable alloys and nanostructured biocomposites as the next-generation biomaterials, and creating new surface modification strategies and biodegradable composites to regulate their degradation rates, will be discussed. Degradation of bioalloys and composites and their in vitro cytocompatibility with relevant host cells, and functional evaluation in animal models in vivo will be presented. |