| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
Cell-Laden Bioink Circulation-Assisted Inkjet-Based Bioprinting to Mitigate Cell Sedimentation and Cell Aggregation |
| Author(s) |
Jiachen Liu, Md Shahriar, Changxue Xu |
| On-Site Speaker (Planned) |
Jiachen Liu |
| Abstract Scope |
Bioink, as the building block for 3D bioprinting, generally composes of solution of biological materials and living cells. During inkjet bioprinting, since the gravitational force acting on cells is usually greater than the buoyant force provided by the solution of biological materials, cells sediment to form cell aggregates through cell-cell interaction. Cell sedimentation and cell aggregation results in highly nonuniform cell distribution within the bioink reservoir, undermining the printing performance and reliability in several aspects such as nozzle performance, droplet formation, and post-printing cell output, which is recognized as a significant challenge in achieving reliable bioprinting. To alleviate this problem, this study proposes a bioink circulation system to assist inkjet bioprinting without manipulation of bioink properties. Results demonstrate a high effectiveness of the proposed system in mitigating cell sedimentation and cell aggregation, therefore improving the bioprinting performance and reliability. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |