| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
Migration Behavior of Invasive and Non-invasive Breast Cancer Cells on a Graded Micropillar Surface |
| Author(s) |
Marielena Molinares Ponce, Changxue Xu |
| On-Site Speaker (Planned) |
Changxue Xu |
| Abstract Scope |
Study of cancer cell migration plays a critical role in understanding of the mechanisms and signals that regulate tumor invasion and metastasis. Cancer cell migration and invasion to surrounding tissues involve alterations in cell adhesion, cytoskeletal reorganization, and signaling pathways as well as complex interaction with the extracellular matrix in the microenvironment. In this study, graded micropillar-based substrates have been utilized to mimic the topography of the extracellular matrix. Two types of breast cancer cells have been utilized including MCF-7 and MDA-MB-231. The corresponding cellular morphology and migration behavior have been investigated in terms of aspect ratio, migration speed and trajectory with the incubation time. Moreover, the cellular behavior is investigated on a curved 3D surface and compared with that on a 2D surface. |
| Proceedings Inclusion? |
Planned: |