| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Bioactive Composite Nanocoatings Fabricated by Advanced Laser Processing to Target Resistant Superbugs |
| Author(s) |
Rodica Cristescu, Anita Ioana Visan, Consuela Elena Matei, Dan Eduard Mihaiescu, Mariana Carmen Chifiriuc, Roger J. Narayan, Douglas B. Chrisey |
| On-Site Speaker (Planned) |
Rodica Cristescu |
| Abstract Scope |
The rising prevalence of antibiotic-resistant pathogens highlights the need for novel antimicrobial agents. Antimicrobial peptides (AMPs) are gaining recognition as a potential substitute for traditional antibiotics, particularly in the treatment of infections that are resistant to medication and those associated with biofilms. In this study, Matrix Assisted Pulsed Laser Evaporation (MAPLE) was successfully used to fabricate bioactive composite nanocoatings consisting of nanoencapsulated AMPs in mesoporous biopolymeric/magnetic nanoparticles. SEM and TEM were used to inspect coating uniformity and nanoparticle shape; chemical investigation was performed by FT-IR. Using culture-dependent qualitative and quantitative methods, the antimicrobial activity was evaluated on ESKAPE “superbug” pathogens in planktonic and biofilm growth states. The biocompatibility was investigated via in vitro models. These studies indicate that the MAPLE-deposited nanocoatings are biocompatible and suitable for releasing the nanoencapsulated AMPs in active form. These coatings could be used to prevent biofilm formation and enhance the performance of medical devices. |