| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biodegradable Materials for Medical Applications II
|
| Presentation Title |
Corrosion Products of Zinc Implant Degradation Suppress Neointimal Hyperplasia |
| Author(s) |
Roger J. Guillory, Timothy Kolesar , Jaroslaw Drelich , Jeremy Goldman |
| On-Site Speaker (Planned) |
Roger J. Guillory |
| Abstract Scope |
Zinc-based materials are emerging as promising degradable metals for arterial stenting. While most in vivo investigations of degradable materials focus on implant degradation behavior and macro tissue responses, few have explored the interactions between intracellular signaling molecules and corrosion products. Here, we investigate the role of the Zn2+ ion in mediating recently reported suppressive effects against smooth muscle cells (SMCs). Cross sections of zinc implants within the abdominal aorta were probed for markers of apoptosis within the neointima. An increase in active caspase-3 and TUNEL signal were found relative to platinum control wires, along with a reduction in SMC coverage. The work demonstrates a caspase-3 dependent intracellular signaling mechanism of SMC apoptosis stimulated by Zn2+. These findings suggest that Zn2+ ions released from degrading zinc implants may impart suppressive effects against neointimal growth, similar to the action of synthetic drugs incorporated into a polymer surface on drug eluting stents (DES). |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |