| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Bone's Adaptation to Hyperglycemia in Diabetes |
| Author(s) |
Claire Acevedo |
| On-Site Speaker (Planned) |
Claire Acevedo |
| Abstract Scope |
With the global epidemic of diabetes, understanding the mechanisms underlying diabetic bone fragility is an urgency. Contrary to standard bone fragility diseases such as osteoporosis, type 2 diabetes is not associated with a low bone mass but it is clearly caused by changes in bone quality. Using a rat model of Type 2 Diabetes Mellitus combined with multi-scale synchrotron experiments from the nanoscale to the macroscale, we demonstrate that diabetes significantly reduces whole-bone strength and toughness for a given bone mass, and we quantify the roles of T2DM-induced deficits in material properties versus bone structure in long bones, vertebrae, and discs. Deficits in material properties in diabetic rat bones are a bone adaptation to increased advanced glycation end-products and impaired collagen fibril deformation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Mechanical Properties |