| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Mechanobiology of Cellular Adhesion Proteins and Their Role in Cancer Progression |
| Author(s) |
Dinesh Katti, Kalpana Katti, Hanmant Gaikwad, Sharad Jaswandkar, Preetham Ravi |
| On-Site Speaker (Planned) |
Dinesh Katti |
| Abstract Scope |
Cellular adhesion proteins, the integrins, E-cadherins, and the cytoskeletal protein actin play a pivotal role in cancer progression. Here, we present the mechanobiology of these adhesion proteins and their potential impact on cancer progression. Integrins are transmembrane proteins that bridge the extracellular matrix to the cell cytoskeleton and enable cell migration, proliferation, and differentiation. In addition to the mechanical response of integrin, we found the mechanism of the outside-in signaling and the role of various biomaterials on cellular signaling that expounds the observed cellular responses on them. E-cadherins are proteins responsible for cell-cell adhesion. For the first time, we constructed the E-cadherin-catenin-actin complex to investigate the inside-out and outside-in signaling mechanisms at cell-cell adhesion junctions. Our findings describe the mechanism of the structural transition of E-cadherin extracellular domains from an X-dimer form to a strand-swap dimer form. This work reveals the crucial role of adhesion protein mechanics on cancer progression. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Computational Materials Science & Engineering, Modeling and Simulation |