| Abstract Scope |
In this study, microneedles were produced by a DLP 3D printer. They were coated with gentamicin-loaded polyvinyl alcohol (PVA)/sucrose solution by dipping method. Characterization tests were performed on microneedles. A fourier transform infrared (FTIR) spectrometer was used to investigate their molecular structures. Morphological analysis of microneedles was carried out using a scanning electron microscope (SEM). Mechanical properties were analyzed using a tensile testing device. In vitro drug release test was performed on microneedles via UV-Vis spectrophotometer.
As a result, coated microneedles were produced by dipping the drug-loaded solution enabling sustained release. Coated microneedles were successfully studied for the usability of transdermal drug delivery systems.
Keywords: Microneedle, 3D printing, gentamicin, drug release. |