| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Student Poster Contest + Rapid Fire
|
| Presentation Title |
C-32: Detection of TIC-relevant Phenotypes with a Multichannel Miniaturized Dielectric Coagulometer Incorporating Bioactive Reagent-functionalized Electrodes |
| Author(s) |
Si Young Song, Michael Suster, Sina Pourang, Christopher Delianides, Dante Disharoon, Selvin Hernandez, Calvin Abonga, Hanif Alizadeh, Sanjay Ahuja, Matthew Neal, Anirban Sen Gupta, Pedram Mohseni |
| On-Site Speaker (Planned) |
Si Young Song |
| Abstract Scope |
Traumatic injury can lead to hemorrhage caused by trauma-induced coagulopathy (TIC), manifesting as a dysfunction in platelets, coagulation factors, or the fibrinolytic system, the three primary components of hemostasis. Timely identification of the dysregulated component is essential to guide resuscitation before exsanguination; however, current diagnostic tools are unsuited for point-of-injury/point-of-care (POI/POC) application, requiring that a patient be transported to a hospital before
diagnosis can begin. To overcome this limitation, we developed a multi-channel miniaturized dielectric coagulometer for POI/POC deployment that uses bioactive material-coated electrodes to probe component-specific hemostatic function. Three types of electrodes were engineered: platelet-activating electrodes coated with thrombin receptor activating peptide 6 (TRAP-6), coagulation factor-activating electrodes coated with lipidated tissue factor (TF), and fibrinolysis-inhibiting lectrodes
coated with aprotinin. These electrodes were individually sensitive to TIC-relevant coagulopathies recapitulated in vitro; when combined in our multi-channel coagulometer, they could be used to diagnose TIC with high specificity. |